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N. Brio's beaker is a recurring item in the Crash Bandicoot series. It is a glass beaker containing a potion which can be green, red or purple.

Crash Bandicoot

N. Brio's beakers first appear in Crash Bandicoot. They are used by N. Brio in his boss fight. When he throws the green ones, they turn into enemies known as blobs. Jumping on these will defeat them and also remove a portion of Brio's health. He also throws red potions which explode (in the N. Sane Trilogy, the red potions have been changed to purple). Later in the fight, he drinks his own potions, turning him into a monstrous version of himself.

Purple vials also act as the main weapon of the Lab Assistants in the levels Slippery Climb, The Lab and Stormy Ascent. Blobs also appear in The Lab.

Crash Team Racing

N. Brio's beaker appears as a usable weapon in Crash Team Racing. When it is not juiced up, it appears green. When an unsuspecting driver hits it, it makes them briefly spin out of control. When juiced up, it appears red and will inflict one of three effects, chosen randomly. The victim may have their item wheel randomized, have their wheels become slippery or simply slow down for a period of time. Other nearby explosions, such as TNT or nitro explosions, set it off too. The player normally drops the beaker behind them, but can also launch beakers forward by holding Up and pressing Circle. Papu Papu and Nitros Oxide use both kinds of beakers in their boss races.

In the sequel, Crash Nitro Kart, these were replaced by Static Orbs and Ice Mines, which serve as similar weapons.

Crash Twinsanity

In Crash Twinsanity, Brio's beaker returns. After being blown off N. Gin's ship, a boss fight begins against N. Tropy and N. Brio on a small iceberg. Here, N. Brio downs a potion from one of his beakers to transform into a new, frog-like monster, chasing Crash around the iceberg before returning to the water for N. Tropy's phases of the fight.

Crash of the Titans (Nintendo DS)

Nitroglycerin is an On-Demand Item that Crash can collect. When its icon is tapped on the touch screen, it creates a shock wave around Crash that damages enemies.

Crash: Mind Over Mutant

In Crash: Mind Over Mutant, Doctor Neo Cortex uses one of N. Brio's potions to transform into a titan. Cortex describes it as a mutation formula tasting "like peppermint barf".

Crash Team Racing Nitro-Fueled

N. Brio's beakers return in the game Crash Team Racing Nitro-Fueled. Unlike before, the juiced up version of the beaker has the same effect every time: causing a racer to spin out, rerolling their weapon (if they have one) and creating a storm cloud above their head, slowing them down for eight seconds.

Crash Bandicoot: On the Run!

Potions in this game (known as serums) are a craftable item used to defeat bosses. They are created at Coco's base by acquiring specific materials and waiting a certain amount of time.

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